This Thursday (October, 29th) at 3pm, Ines Simoes, a PhD student from the Laboratory of Mitochondrial Biology and Metabolism, will present her work entitled: The role of hypercaloric diets in the development and progression of Non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can progress to inflammatory Non-alcoholic steatohepatitis (NASH) and may culminate with chronic liver failure. The progression of steatosis towards NASH has been described to be associated with mitochondrial‐induced reactive oxygen species production and to mitochondrial dysfunction. However, it is still not clarified the sequence of events that link mitochondrial-redox alterations to the pathophysiology of NAFLD. Therefore, in my PhD research project, I have hypothesized that the onset of a pro-oxidant state act as the trigger to mitochondrial and hepatic-related alterations that may drive by a non-reversible way the disease progression into NASH. Using an in vivo NAFLD mice model, I have addressed the distinct role of hypercaloric diets (fat, sucrose or combined fat and sucrose) in an early stage of NAFLD. In fact, new insights about the mechanisms governing hepatic oxidative damage were provided. Furthermore, I have investigated the specific end-points for mitochondrial dysfunction that govern NAFLD progression along time.
We will most probably meet via a new platform, I will send the instructions at the beginning of this week.