This Thursday, October 8th, 3pm within the framework of the Nencki Institute’s seminars, Julian Swatler, a PhD student in the group of Prof. Katarzyna Piwocka, will present his project entitled: „Role of leukemic extracellular vesicles in differentiation and suppressive activity of regulatory T cells”
Chronic myeloid leukemia (CML) is a hematological malignancy that develops in the bone marrow. CML development is facilitated by immunosuppressive immune cells, including regulatory T cells (Treg). However, mechanisms and leukemia-derived factors that control Treg biology in leukemia are practically unknown. We hypothesized that leukemic extracellular vesicles (EVs) – small vesicles released outside the cell, may be a contributing factor. Using both mouse and human ex vivo systems I have studied the direct effect of chronic myeloid leukemia-derived EVs on activity, suppressive phenotype and differentiation of regulatory T cells. Furthermore, mass spectrometry and signalling studies provided more insight about precise regulatory pathways of observed phenomena. Finally, I will show data from in vivo mouse models of leukemia that further dissect leukemic EVs-Treg interaction in the physiological context of disease development.
Please use this meeting ID: meet.google.com/eeh-stxq-ojc
Please also make sure you mute your microphones during the talk.