Tydzień Mózgu 2022 w Instytucie Nenckiego

Szanowni Państwo,

Fundacja Marcelego Nenckiego Wspierania Nauk Biologicznych oraz Instytut Nenckiego mają przyjemność zaprosić wszystkich zainteresowanych na Tydzień Mózgu 2022 w Instytucie Nenckiego.

Temat przewodni tegorocznego Tygodnia Mózgu w Instytucie Nenckiego to: „Zagadki Neuroplastyczności”

Zapraszamy Państwa na 5 wykładów online w dniach 14-18 marca o godzinie 17.00:

Prof. dr hab. Małgorzata Kossut, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN


poniedziałek 14.03.2022 godz. 17.00, link do wykładu: https://zoom.us/j/99970186013

Prof. dr hab. Leszek Kaczmarek, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

„Neuroplastyczny umysł molekularny”

wtorek 15.03.2022 godzina 17.00, link do wykładu: https://zoom.us/j/97616937577

Dr n. med. Marcin Leśniak, Wydział Psychologii Uniwersytetu Warszawskiego

“Terapia zaburzeń poznawczych po udarze mózgu – czy to działa?”

środa 16.03.2022 godzina 17.00, link do wykładu: https://zoom.us/j/97843674771

Prof. dr hab. Katarzyna Jednoróg, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

“Jak nauka czytania zmienia mózg”

czwartek 17.03.2022 godzina 17.00, link do wykładu: https://zoom.us/j/99908662486

Dr Łukasz Bola, Instytut Psychologii PAN

“Co robi kora wzrokowa osoby niewidomej? O plastyczności mózgu wywołanej utratą wzroku”

piątek 18.03.2022 godz. 17.00, link do wykładu: https://zoom.us/j/98805447988

Szczegółowe informacje o wykładach wkrótce na stronach:





Nencki Institute Seminar

Dear All

I would like to cordially invite you to the Nencki Institute Seminar which will take place online next Thursday, March 3rd at 3 pm.

We will host Dr. José Pedro Friedmann Angeli a group leader at the Rudolf-Virchow-Zentrum – Center for Integrative and Translational Bioimaging, who works in the area of ferroptosis.

Please use the following link:


Meeting ID: 982 2223 1110
Passcode: 795926

Best regards,
Aleksandra Pękowska

Seminarium Doktorantów

Szanowni Państwo,

Serdecznie zapraszamy na Seminarium Doktorantów, które odbędzie się 4 marca 2022 roku o godz. 10.30 w Sali Konferencyjnej CN (I piętro). W programie przewidziane są 4 prezentacje:

  1. Magdalena Baszuk
  2. Mateusz Choiński
  3. Karolina Rojek-Sito
  4. Aleksandra Sęk

Informacje dotyczące prelegentów wraz z abstraktami znajdują się poniżej.

Seminarium odbywać się będzie w trybie hybrydowym. Osoby będące na Sali CN (prelegenci i ich promotorzy) proszone są o stosowanie zasad bezpieczeństwa.

Link do spotkania


Z pozdrowieniami,
Anna Filipek & Anna Nowicka

Mgr Magdalena Baszuk

Laboratory of Neuropsychology

Supervisor I: Prof. dr hab. Elżbieta Szeląg

Supervisor II: Dr hab. Hanna Bednarek

Title: Training in temporal information processing ameliorates cognitive functions in healthy elderly: neuropsychological and electrophysiological evidence



We are aging society. The age-related decline concerns many cognitive domains. Previous studies conducted in our Laboratory indicated that these deteriorations are accompanied by deficient Temporal Information Processing (TIP) which is an essential component of human cognition and provides a framework for many mental functions.

This study aimed to verify cognitive benefits of cognitive training based on TIP.

Subjects were 69 elderly aged from 61 to 79 years (M=68.51; SD=4.07) classified randomly into three groups: (1) cognitive training in TIP using Dr Neuronowski program (experimental Group A); (2) placebo training (active control Group B); and (3) non-active controls (Group C, without any training). All participants completed pre-test and post-test assessment. Each training took 8 weeks and consisted of 24 sessions. The stability of observed effects was evaluated in follow-up assessment. Evaluation included neuropsychological and electrophysiological procedures.

After the training we observed significant improvement only in Group A which was stable in follow-up assessment. The cognitive benefits comprised: TIP, executive functions, short-term memory and inhibitory control. Our results indicated the high effectiveness of cognitive training based on TIP. It might be expected that improvement in TIP may lead to improvement of cognitive functions in elderly. Supported by NCN GrantNumber 2015/17/B/HS6/04182.


Mgr Mateusz Choiński

Laboratory of Neuropsychology

Supervisor: Dr hab. Aneta Szymaszek

Title: The efficacy of aphasia treatment based on temporal information processing – neuropsychological and electrophysiological markers


Aphasia is an acquired impairment in language functions resulting from a brain lesion. Traditional therapy of people with aphasia (PWA) includes language exercises directly improving deficient functions. Recently, it was evidenced that aphasia is accompanied by deficits in non-language cognitive functions, which intensify language difficulties.

In our Laboratory, the innovative therapeutic tool Dr. Neuronowski®based on exercises involving temporal information processing (TIP), was developed. TIP is a neural frame for many cognitive functions, including language.

The aim of the study was to compare the efficacy of two training programs: a traditional language therapy and the novel therapy based on TIP exercises using Dr. Neuronowski®.

Beside broad neuropsychological assessment of PWA, they were tested with two event-related potentials (ERPs) procedures: P300 and Mismatch Negativity.

Both trainings improved language (phoneme discrimination, sentence comprehension, verbal fluency) and non-language cognitive functions (planning, TIP). Moreover, training with Dr. Neuronowski® improved working memory and naming. These results suggest the efficacy of the TIP training in aphasia treatment. Moreover, latencies and amplitudes of the components measured before the therapy predicted the effects of both trainings. ERPs, therefore, may be used as the predictive objective tool that should be included into the diagnosis of PWA.

Supported by National Science Centre, Poland, grant number: 2016/21/B/HS6/03775.

Mgr Karolina Rojek-Sito

Laboratory of Neurobiology of Emotions

Supervisor: Dr hab. Ewelina Knapska, prof. Instytutu Nenckiego

Title: Central amygdala – ventral tegmental area – cortical circuits for social and food rewards


Social interaction is a complex behavior essential for the survival of many species, and its impairment is a hallmark feature of major neuropsychiatric disorders. Social dysfunctions are often explained by a deficit in motivation and reward processing specific to social stimuli. However, the functional dissociation between the neural circuits processing social and non-social rewards remains unknown. Here, we compared two cortical circuits connecting the central amygdala (CeA) and ventral tegmental area (VTA), in order to ascertain if they are the underlying motivation for social interaction and for food. Using opsins targeted at behaviorally activated neurons, we tagged CeA cells implicated in social and food reward. Optogenetic manipulations revealed that these circuits only partially overlap. Through chemogenetic manipulations of specific projections, we identified a crucial role of the CeA-VTA pathway and the dopaminergic VTA-anterior cingulate (ACC) and VTA-orbitofrontal cortex (OFC) pathways in social motivation, but not in terms of motivation for a food reward. In addition, we found that the ACC-CeA and OFC-CeA inputs are involved in both social and non-social motivation. Together, these findings establish the CeA-cortical pathways as a node for regulating social motivation, providing new insights into the regulation of social reward.

The project was supported by European Research Council Starting Grant (H 715148) to EK.



Mgr Aleksandra Sęk

Laboratory of Intracellular Ion Channels (Interdisciplinary Doctoral Studies TRI-BIO-CHEM)

Supervisor I:  Prof. dr hab. Adam Szewczyk

Supervisor II: Prof. dr hab. Tomasz Bauer (Faculty of Chemistry, University of Warsaw)

Research tutor: Dr hab. Piotr Bednarczyk, prof. SGGW

Title: Mitochondrial BKCa channel: regulation by synthetic and natural compounds


Mitochondria play a central role in energy metabolism, cellular signaling and ions homeostasis. It has been shown that mitochondrial potassium channels present in the inner mitochondrial membrane have been involved in cytoprotection during ischemia/reperfusion event. One of these channels is the mitochondrial large-conductance Ca2+– regulated potassium (mitoBKCa) channel. Activation of the mitoBKCa channel is important for protecting heart tissue against ischemic damage.

One of the objectives of the study was identification of the potassium channels in human bronchial epithelial cells and characterization the channels activity in the HEK293 cell line expressing the mitochondrial BK_DEC isoform. The project also focuses on the regulation of the mitoBKCa channel by plant origin compounds and their synthetic derivatives. Measurements of the channel activity were performed with the use of patch-clamp technique and biochemical methods were applied to monitor physiological role of the compounds. In summary, new mitoBKCa channel was described in epithelial cells and new naringenin derivatives as channel regulators were identified. Detailed analysis of regulation of mitoBKCa channel is crucial for better understanding of cytoprotection induced by potassium channel openers.

This study was supported by a grant 2019/35/B/NZ1/02546 from the NCN, Poland and partially by Nencki Institute. Work implemented as a part of Operational Project Knowledge Education Development 2014-2020 co-financed by European Social Fund: POWER.03.02.00-00-I007/16-00 (to A. Sęk).

Obrona Rozprawy Doktorskiej

11 marca 2022 r. o godz. 12:00 odbędzie się on-line publiczna obrona rozprawy doktorskiej na stopień doktora nauk ścisłych i przyrodniczych w dyscyplinie nauki biologiczne mgr. Michała Szczepanika pt. “Neural Correlates of Emotional Contagion in Humans: Familiarity Between Participants Does Not Enhance Transmission of Fear”

Promotor: dr hab. Ewelina Knapska, prof Instytutu Nenckiego PAN
Promotor pomocniczy: dr Marek Wypych
Recenzenci: prof. dr hab. Przemysław Bąbel, dr hab. Monika Wróbel, prof. UŁ, prof. Claus Lamm

Link do obrony: https://zoom.us/j/93994520821?pwd=K0RQWnNMbys5cGd5TnFJa1lDTlR6QT09

Link do streszczenia i recenzji: https://cloud.nencki.gov.pl/d/c69b11b468/

You are invited to a Zoom webinar
When: Mar 11, 2022 12:00 AM Warsaw
Topic: Obrona pracy doktorskiej mgr. Michała Szczepanika

Please click the link below to join the webinar:


Passcode: 130381
Or One tap mobile:
Poland: +48223987356,,93994520821#,,,,*130381# or +48223065342,,93994520821#,,,,*130381#

Or Telephone:
Dial(for higher quality, dial a number based on your current location):
Poland: +48 22 398 7356 or +48 22 306 5342 or +48 22 307 3488
Webinar ID: 939 9452 0821
Passcode: 130381
International numbers available: https://zoom.us/u/adYvdpGOPZ

SPARK Europe Education Webinar

Dear All,

Nencki Institute as a representative of SPARK Poland within SPARK Europe would like to cordially invite you to participate in the next webinar of European SPARKs joint series on March 2nd16-17 CET.

In this SPARK Europe Webinar titled „Drugs – from discovery to market – regulatory strategy, submission package, and marketing approval „ Dr. Sara Blumenstein will provide us with an overview of the type of drugs and biologics, approval regulatory pathways, and drug development process in general. Dr. Sara Blumenstein is the Pharma and Biotechnology Regulatory Section Manager at Gsap with over 20 years of experience in biotechnology and cell therapy fields. Gsap is an international consulting firm for healthcare companies, providing end-to-end services throughout the life cycle of medical products.

The series of webinars is open for all students and employees of SPARK-associated organizations (Nencki Institute PAS and International Institute of Molecular and Cell Biology in Warsaw).

Registration to the webinar is required in advance. Please register at:


latest on March 1st. With later registrations, access cannot be guaranteed. There are a limited number of places available and they are filled in in the order of registration.

As a reminder, the fall 2021 webinar series takes place biweekly on Wednesday at 16 -17 CET and covers topics from design thinking to challenges in selling complex high-tech products from top-quality speakers around Europe and the US.

Best regards,
Paulina Santus