Dear All

I would like to cordially invite you to the next Nencki Institute seminar which will take place online on the 13^th of January at 3pm. Dr. Michal Gdula, who is a head of the Developmental Epigenetics lab at the Institute of Molecular Biology and Biotechnology in Poznan, will present his work on the relationship between epigenetic modifications of chromatin, the three-dimensional structure of the genome and mammalian development.

To connect please use the following information:

https://zoom.us/j/98222231110?pwd=Uyt6Q29BaGlLSXBsUnJRQnpWc0pJZz09 

Meeting ID: 982 2223 1110
Passcode: 795926

Wishing you all the best in 2022!
Aleksandra Pekowska

Szanowni Państwo,

Serdecznie zapraszamy na seminarium Doktorantów, które odbędzie się 14 stycznia 2022 roku o godz. 10.30 w Sali Konferencyjnej CN (I piętro). W programie przewidziane są 3 prezentacje:

1. Joanna Beck
2. Michał Niziołek
3. Patrycja Kruk

Informacje dotyczące prelegentów wraz z abstraktami znajdują się poniżej.

Seminarium odbywać się będzie w trybie hybrydowym. Osoby będące na Sali CN  (prelegenci i ich promotorzy) proszone są o stosowanie zasad bezpieczeństwa.

Link do spotkania: https://zoom.us/j/99391829934?pwd=SWwxWjN3aldpRnNsQXppOXNtK0V5QT09

Z pozdrowieniami i życzeniami szczęśliwego Nowego Roku,

Anna Filipek & Anna Nowicka

Joanna Beck
Laboratory of Language Neurobiology
Supervisor: dr hab. Katarzyna Jednoróg

Title: “Letters and speech sounds associations in typical and atypical reading development”

Abstract:

The first and critical step in reading development is learning letter-speech sound (LS) associations. The pace of learning LS associations depends on orthographic transparency – the degree of regularity in LS correspondence, though learning trajectories in Polish are unknown. Successful acquisition of LS association is a predictor of later reading skills and left superior temporal cortex (STC) plays an important role in forming LS associations. Its disruption was implicated in dyslexia, though if it is genuine effect or a consequence of decreased reading experience is undetermined. Finally, little is known about the process LS association in the blind. To better understand LS integration in typical and atypical reading development (dyslexia and blindness) we conducted four experiments using behavioral methods and fMRI. Polish children master LS associations within two years of reading instruction, but LS automatization takes longer. Differences in brain activation to LS association can be found at a very early stage of reading instruction. Dyslexia significantly affects LS association in the left STC, with lower brain response to conflicting LS compared to both age and reading matched controls. LS integration occurs in the blind brain though it is different from the sighted, possibly reflecting their lower exposure to reading.

Michał Niziołek
Laboratory of Cytoskeleton and Cilia Biology
Supervisor:  dr hab. Dorota Włoga

Title: “Proximo-distal and circumferential differences in ciliary proteins’ localization in a ciliate Tetrahymena thermophila.”

Abstract:

Motile cilia are several micrometers long, microtubule-based hair-like cell protrusions. The ultrastructure and protein composition of cilia are highly evolutionarily conserved from protists to mammals. We have found that there are proximo-distal and circumferential differences in the localization of components of some ciliary complexes.

Tetrahymena paralogous proteins, CCDC146A and CCDC146B have complementary ciliary localization. CCDC146A localizes in the distal half of the cilium, whereas CCDC146B is present in the proximal part. When N-terminal fragments are exchanged between paralogs, chimeric proteins are present in the whole cilia. CCDC146A and CCDC146B interact with CCDC47C forming a minor complex positioned close to outer dynein arms (ODAs) and nexin-dynein regulatory complexes, and their lack differently affects cilia motility suggesting that the same ultrastructural defects may cause various phenotypic outcomes depending upon the position of the defect along the cilium length.

CCDC114 and CCDC151 are highly evolutionarily conserved proteins, subunits of the ODAs docking complex. The genome of Tetrahymena encodes 7 paralogs of CCDC114. These paralogs localize differently not only along the cilium length (cilium base, proximal and distal parts) but also at cilium circumference. Because during the power and recovery stroke, base, proximal, and distal parts of the cilium bend in their own way, we hypothesize that such differences are correlated with the presence of various protein paralogs.

Patrycja Kruk
Laboratory of Cell Biophysics
Supervisor: dr hab. Joanna Dzwonek, prof. IBD

Title: “Astrocytic CD44 deletion in the dentate gyrus influences epileptogenesis”

Abstract:

Epilepsy is one of the most common chronic neurological diseases affecting around 0.5-1.0% of the human population. The source of most cases of epilepsy is unknown. Highly expressed in astrocytes CD44 protein, a transmembrane receptor for hyaluronan, is believed to play an important role in reactive astrogliosis in pathological conditions in the brain. To study the CD44-depended astrocyte-neuron relationship in epileptogenesis, the kainic acid (KA) model of temporal lobe epilepsy (TLE) was used, where mice undergo intrahippocampal KA injections provoking status epilepticus and further recurrent seizures. Whereas wild-type mice injected with KA show similar to human neuropathological and electroencephalographic (EEG) TLE features, those with a previously activated conditional CD44 knock-out in astrocytic cells in the dentate gyrus develop a different seizure pattern. Their EEG recordings show the seizures they experience are more frequent than those in the control group, but their severity is lower. While control group mice experience more whole body clonic/clonic-tonic attacks, CD44 knock-out often does not show any behavioral symptoms of a seizure at all. These results indicate astrocytic CD44 plays a crucial role in epileptogenesis and seizure development and may provide a possible alternative pathway for future drug discovery.

Szanowni Państwo,

Zapraszamy do wysłuchania kolejnego wykładu w ramach cyklu „Nowe Oblicza Biochemii 2022” organizowanego przez Polskie Towarzystwo Biochemiczne. Webinar on-line odbędzie się 13 stycznia 2022 r., o godz. 13:00.

Wykład (po polsku) wygłosi prof. Ewa Zuba-Surma (Wydział Biochemii, Biofizyki i Biotechnologii UJ, Małopolskie Centrum Biotechnologii, Kraków): „Pęcherzyki zewnątrzkomórkowe z komórek macierzystych – nowe narzędzia w naprawie tkankowej”

Osoby zainteresowane wykładem prosimy o rejestrację na platformie ZOOM WEBINAR:
https://zoom.us/webinar/register/WN_624-5C2wTWuKW5CoVei2Ag

Dear All,

After a short break, we are back with the new European SPARK Education Series, Spring 2022 Edition. Nencki Institute as a representative of SPARK Poland within SPARK Europe would like to cordially invite you to participate in the upcoming webinar on January 12th, 16-17 CET.

During the „Financing in Health Tech and Life Science Business”, Pasi Sorvisto will provide us with some advice and perspectives on financing aspects in the biotech industry, existing financing instruments, and financing portfolio-building for each stage of a company. Pasi is a founder of SPARK Finland, a Director of SPARK Europe, and a member of SPARK Global Steering Committee. He is an internationally acknowledged business and finances professional – specialized in sensor systems, health IT, and bioinformatics – with more than 20 years of experience as an entrepreneur, consultant, early-stage financier, and advisor. In the flayers, you can find detailed information on the webinar as well as the list of lectures of the Spring 2022 Edition.

The series of webinars is open for all students and employees of SPARK-associated organizations (Nencki Institute PAS and International Institute of Molecular and Cell Biology in Warsaw).

Registration to the webinar is required in advance.

Please register at: https://tuni.zoom.us/meeting/register/u50qf-2qqj4iG9SdDYuL_ETM66lVjgaRpwW5 latest on January 11th.

With later registrations, access cannot be guaranteed. There are a limited number of places available and they are filled in in the order of registration.

As a reminder, the Spring 2021 webinar series takes place biweekly on Wednesday at 16 -17 CET and covers topics from design thinking to challenges in selling complex high-tech products from top-quality speakers around Europe and the US.

Best regards,
Paulina Santus

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN poszukuje kandydata na stanowisko: Kierownik Biblioteki

Wymagania:

– wykształcenie kierunkowe : studia wyższe z informacji naukowej i bibliotekoznawstwa,
– doświadczenie w pracy w bibliotece o charakterze naukowym
– bardzo dobra znajomość języka angielskiego w mowie i piśmie, (poziom B2/C1)
– mile widziana znajomość programu bibliotecznego HORIZON i formatu MARC21,
– znajomość przepisów katalogowania i zasad RDA,
– bardzo dobra organizacja pracy,

Zakres zadań na stanowisku:

– kierowanie Działem
– nadzór nad katalogowaniem książek oraz artykułów z czasopism i prac zbiorowych
– nadzór nad prowadzeniem i bibliografią wydawnictw zagranicznych
– prenumerata czasopism polskich, zagranicznych i baz danych
– organizowanie przetargów na czasopisma

Dokumenty proszę przesyłać na adres: hr@nencki.edu.pl do 14 stycznia 2022 roku z dopiskiem „biblioteka”.